Bromomethylcyclopropane → HCID 22105514, compound

HRID 1455951Notes

Reaction equation

HRID 1455951 reaction equation
[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][C:10]=1[CH2:11][NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:29]1([CH2:32]Br)[CH2:31][CH2:30]1>>[CH2:1]([O:8][C:9]1[CH:27]=[CH:26][C:25]([Br:28])=[CH:24][C:10]=1[CH2:11][N:12]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:15][N:14]=1)[CH2:32][CH:29]1[CH2:31][CH2:30]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 22105508HCID 22105508, compound

Product 1

HCID 22105514HCID 22105514, compound

Procedure

Ethyl 2-[N-(2-benzyloxy-5-bromobenzyl)-N-(cyclopropyl-methyl)amino]pyridine-5-carboxylate was prepared from ethyl 2-[N-(2-benzyloxy-5-bromobenzyl)amino]pyridine-5-carboxylate and cyclopropylmethyl bromide by a similar method to that described in Reference example 5, purifying the product by MPLC and eluting with 80% dichloromethane in hexane.

Workup

  1. custompurifying the product by MPLC
  2. washeluting with 80% dichloromethane in hexane

Sources & evidence

ORD record
ord-c1e33eba55e1400e8a3f5107882de732
Source dataset
uspto-grants-1998_12
Patent number
US05843942

Reaction notes

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