Methylhydrazine → HCID 22105873, compound

HRID 1456005Notes

Reaction equation

HRID 1456005 reaction equation
C(N(CC)CC)C.[CH3:8][NH:9][NH2:10].[CH2:11]([N:13]1[C:18](S(C)=O)=[C:17]([C:22]#[N:23])[C:16](=[O:24])[N:15]2[N:25]=[CH:26][CH:27]=[C:14]12)[CH3:12]>C(O)C>[NH2:23][C:22]1[N:9]([CH3:8])[N:10]=[C:18]2[C:17]=1[C:16](=[O:24])[N:15]1[N:25]=[CH:26][CH:27]=[C:14]1[N:13]2[CH2:11][CH3:12]

Participants

5

Reactant 3

HCID 6061MethylhydrazineHCID 8471TriethylamineHCID 22105859HCID 22105859, compound

Product 1

HCID 22105873HCID 22105873, compoundYield 39.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Triethylamine (1.44 g) and methylhydrazine (1.44 g) were added to a solution of 3.25 g of 4-ethyl-5-methanesulfinyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitrile in 60 ml of ethanol. The mixture was stirred at room temperature for 10 minutes and then stirred at 100° C. for 20 minutes. The reaction mixture was ice-cooled and the crystals precipitated were collected by filtration and sequentially washed with ethanol, methanol and diethyl ether to provide 1.2 g of the title compound as colorless crystals. The structure and melting point of the compound obtained are shown in Table 1.

Workup

  1. stirringstirred at 100° C. for 20 minutes
  2. temperaturecooled
  3. customthe crystals precipitated
  4. filtrationwere collected by filtration
  5. washsequentially washed with ethanol, methanol and diethyl ether

Sources & evidence

ORD record
ord-002fc19a675f46b3ba65e16ae9335444
Source dataset
uspto-grants-1998_12
Patent number
US05843951

Reaction notes

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