反应详情

To a stirred solution of 1.1 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 1.5 mmol of triethylamine. To the mixture is added 1.1 mmol of 9,10-dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine and the mixture is stirred for 5 hours. The reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine. The reaction mixture is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent to give the desired product as a solid.

1. washThe reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine
2. dry with materialThe reaction mixture is dried with Na2SO4
3. filtrationfiltered
4. customevaporated in vacuo
5. customto give a solid which
6. customis purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent