反应详情

To a stirred solution of 5 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 7 mmol of triethylamine and 5 mmol of 6,7-dihydro-5-(4-aminobenzoyl)-5H-pyrrolo[1,2-a][1,5]benzodiazepine. The reaction mixture is washed with water, 2M citric acid, NaHCO3, and brine. The organic layer is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel to give the desired product as a solid; mass spectrum (CI):422(M+H).

1. washThe reaction mixture is washed with water, 2M citric acid, NaHCO3, and brine
2. dry with materialThe organic layer is dried with Na2SO4
3. filtrationfiltered
4. customevaporated in vacuo
5. customto give a solid which
6. customis purified by flash chromatography on silica gel