2-Bromothiazole → HCID 9860114, compound

HRID 1456335Notes

Reaction equation

HRID 1456335 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[F:7][C:8]([F:17])([F:16])[C:9]([C:11]1[S:12][CH:13]=[CH:14][N:15]=1)=[O:10]>CS(C)=O>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[C:9]([C:11]1[S:12][CH:13]=[CH:14][N:15]=1)([OH:10])[C:8]([F:17])([F:16])[F:7]

Participants

4

Reactant 2

HCID 764302-BromothiazoleHCID 221066842,2,2-Trifluoro-1-(1,3-thiazol-2-yl)ethan-1-one

Product 1

HCID 9860114HCID 9860114, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

From 2-bromothiazole and 2-trifluoroacetylthiazole. M.p. 113°-115° C. 13C Nmr (d6 -DMSO) 77.3 (q, J 30Hz), 122.8, 123.0 (q, J 286 Hz), 142.7 and 166.1 ppm. Found: C, 36.25; H, 1.7; N, 10.5. C8H5F3N2OS2 requires C, 36.1; H, 1.9; N, 10.5%.

Sources & evidence

ORD record
ord-b8441b37972741b69adf9e16fff4750d
Source dataset
uspto-grants-1998_12
Patent number
US05843971

Reaction notes

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