反应详情

To 40 ml of aqueous conc. ammonia were added 10.0 g of trans-1,2-cyclohexanedicarboxylic acid anhydride with stirring at room temperature, and the mixture was stirred at room temperature for 4 hours and 15 minutes. The pH of the reaction mixture was adjusted to 1 with conc. hydrochloric acid with stirring under ice-cooling and the precipitated crystalline solid was collected by filtration and washed with water. The crystalline solid was recrystallized from ethanol to obtain 6.93 g of the desired compound as a colorless crystalline solid.

1. stirringthe mixture was stirred at room temperature for 4 hours and 15 minutes
2. stirringwith stirring under ice-
3. temperaturecooling
4. filtrationthe precipitated crystalline solid was collected by filtration
5. washwashed with water
6. customThe crystalline solid was recrystallized from ethanol