Hydrochloric Acid → HCID 15338608, compound

HRID 1456363Notes

Reaction equation

HRID 1456363 reaction equation
CC(=[N:4][O:5][C:6]1[CH:13]=[C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:11]=[CH:10][C:7]=1[C:8]#[N:9])C.Cl>C(O)C>[C:16]1([CH2:15][O:14][C:12]2[CH:11]=[CH:10][C:7]3[C:8]([NH2:9])=[N:4][O:5][C:6]=3[CH:13]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15338607HCID 15338607, compound

Product 1

HCID 15338608HCID 15338608, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

20.2 g (0.072 mol) of 2-[[(1-methylethylidene) amino]oxy]-4-(phenylmethoxy)benzonitrile are reacted with 340 ml of a 4N solution of hydrochloric acid in ethanol for 20 hours and then the solvent is evaporated. The crystalline product is subsequently triturated in dichloromethane, then the mixture is filtered and the solid is dissolved in the minimum amount of lukewarm methanol. The solution is alkalified with ammonia and then diluted with water. After filtration and washing with water, 16.3 g of product are obtained.

Workup

  1. customthe solvent is evaporated
  2. customThe crystalline product is subsequently triturated in dichloromethane
  3. filtrationthe mixture is filtered
  4. dissolutionthe solid is dissolved in the minimum amount of lukewarm methanol
  5. additiondiluted with water
  6. filtrationAfter filtration
  7. washwashing with water, 16.3 g of product
  8. customare obtained

Sources & evidence

ORD record
ord-a709c943ff5e4d46b2873475b1175aa5
Source dataset
uspto-grants-1998_12
Patent number
US05843975

Reaction notes

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