Hydrochloric Acid → HCID 67583566, compound

Participants

Reaction Steps

140 mg of (2R,4R)-2-[2-{2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenoxy}-ethyl]-4-hydroxy-1-methylpyrrolidine [prepared as described in step (c) above] were dissolved in 5 ml of ethyl acetate, and then 0.15 ml of a 4N solution of hydrogen chloride in ethyl acetate were added to the resulting solution. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 113 mg (yield 73%) of the title compound as colorless crystals, melting at 93°-94° C.

Provenance & Evidence