Hydrochloric Acid → HCID 67583566, compound

HRID 1456562Notes

Reaction equation

HRID 1456562 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][C@@H:19]([OH:21])[CH2:18][N:17]2[CH3:22])[CH:5]=[CH:6][C:7]=1[F:8].[ClH:28]>C(OCC)(=O)C>[ClH:28].[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C:11]2[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][C@@H:19]([OH:21])[CH2:18][N:17]2[CH3:22])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67583567HCID 67583567, compound

Product 1

HCID 67583566HCID 67583566, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

140 mg of (2R,4R)-2-[2-{2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenoxy}-ethyl]-4-hydroxy-1-methylpyrrolidine [prepared as described in step (c) above] were dissolved in 5 ml of ethyl acetate, and then 0.15 ml of a 4N solution of hydrogen chloride in ethyl acetate were added to the resulting solution. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 113 mg (yield 73%) of the title compound as colorless crystals, melting at 93°-94° C.

Workup

  1. customThe crystals which precipitated
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-afa65c44d2fe4c919945722e5b299a94
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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