Hydrochloric Acid → HCID 67612085, compound

HRID 1456563Notes

Reaction equation

HRID 1456563 reaction equation
C(OC([N:8]1[CH2:12][C@H:11]([OH:13])[CH2:10][C@H:9]1[CH2:14][CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=1[CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[C:28]([F:33])[CH:27]=1)=O)(C)(C)C.[ClH:34]>O1CCOCC1>[ClH:34].[F:33][C:28]1[CH:27]=[C:26]([CH2:25][CH2:24][C:18]2[CH:19]=[C:20]([F:23])[CH:21]=[CH:22][C:17]=2[O:16][CH2:15][CH2:14][C@@H:9]2[CH2:10][C@@H:11]([OH:13])[CH2:12][NH:8]2)[CH:31]=[CH:30][C:29]=1[F:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67583568HCID 67583568, compound

Product 1

HCID 67612085HCID 67612085, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

83 mg of (2R,4R)-1-t-butoxycarbonyl-2-[2-{2-[2-(3,4-difluorophenyl)ethyl]-4-fluorophenoxy}ethyl]-4-hydroxypyrrolidine [prepared as described in Example 7(b)] were dissolved in 2 ml of dioxane, and then 2 ml of a 4N solution of hydrogen chloride in dioxane were added to the resulting solution. The resulting mixture was then allowed to stand at room temperature for 1 hour. At the end of this time, the crystals which precipitated were collected by filtration, and dried in vacuo, to give 55 mg (yield 77%) of the title compound as colorless crystals, melting at 170°-171° C.

Workup

  1. customAt the end of this time, the crystals which precipitated
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-40a05d3a00fe4b7580463384fbd5816f
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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