Hydrochloric Acid → HCID 67660527, compound

HRID 1456580Notes

Reaction equation

HRID 1456580 reaction equation
[OH:1][C@H:2]1[CH2:6][N:5]([CH3:7])[C@H:4]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=2[CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:3]1.[ClH:27]>O1CCOCC1>[ClH:27].[OH:1][C@H:2]1[CH2:6][N:5]([CH3:7])[C@H:4]([CH2:8][CH2:9][O:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:12]=2[CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54220910HCID 54220910, compound

Product 1

HCID 67660527HCID 67660527, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

385 mg of (2R,4R)-4-hydroxy-2-{2-[5-methoxy-2-(2-phenylethyl)phenoxy]ethyl}-1-methylpyrrolidine [prepared as described in step (b) above] were dissolved in 5 ml of dioxane, and then 0.27 ml of a 4N solution of hydrogen chloride in dioxane were added to the resulting solution. The solvent was then removed by evaporation under reduced pressure. The resulting oily substance was dissolved in 10 ml of ethyl acetate, and allowed to stand at room temperature for about 10 minutes. The crystals which precipitated were collected by filtration, and dried in vacuo, to give 385 mg (yield 91%) of the title compound as colorless crystals, melting at 108°-110° C.

Workup

  1. customThe solvent was then removed by evaporation under reduced pressure
  2. dissolutionThe resulting oily substance was dissolved in 10 ml of ethyl acetate
  3. customThe crystals which precipitated
  4. filtrationwere collected by filtration
  5. customdried in vacuo

Sources & evidence

ORD record
ord-9d6f15c725bf4cecb43c32e9dee677c1
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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