Hydrochloric Acid → HCID 67584709, compound

HRID 1456590Notes

Reaction equation

HRID 1456590 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([O:14][C:15](=[O:27])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:11][N:10]2[CH3:28])=[C:4]([CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[C:35]([O:40][CH3:41])[CH:34]=2)[CH:3]=1.[ClH:42]>O1CCOCC1>[ClH:42].[F:1][C:2]1[CH:30]=[CH:29][C:5]([O:6][CH2:7][CH2:8][C@@H:9]2[CH2:13][C@@H:12]([O:14][C:15](=[O:27])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:11][N:10]2[CH3:28])=[C:4]([CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[C:35]([O:40][CH3:41])[CH:34]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67583573HCID 67583573, compound

Product 1

HCID 67584709HCID 67584709, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

684 mg of (2R,4R)-2-[2-{4-fluoro-2-[2-(4-fluoro-3-methoxyphenyl)ethyl]phenoxy}ethyl]-4-lauroyloxy-1-methylpyrrolidine [prepared as described in step (a) above] were dissolved in 10 ml of dioxane, and 0.45 ml of a 4N solution of hydrogen chloride in dioxane was added to the resulting solution. The solution was then concentrated by evaporation under reduced pressure. Hexane was added to the residue, and the crystals which precipitated were collected by filtration, and dried in vacuo, to give 485 mg (yield 67%) of the title compound as colorless crystals, melting at 49°-53° C.

Workup

  1. concentrationThe solution was then concentrated by evaporation under reduced pressure
  2. additionHexane was added to the residue
  3. customthe crystals which precipitated
  4. filtrationwere collected by filtration
  5. customdried in vacuo

Sources & evidence

ORD record
ord-e0029c43d96543d78bf67154fbe24d63
Source dataset
uspto-grants-1998_12
Patent number
US05843983

Reaction notes

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