反应详情

To a suspension of compound 705 (600 mg, 1.04 mmol) in CH2Cl2 (10 mL) was added TFA (4.0 mL) and the reaction allowed to stir for 4 hr. The reaction was concentrated in vacuo and the residue co-concentrated with toluene (3×). The residue was dissolved in MeOH (10 mL) and treated with HOAc (2.0 mL) followed by formaldehyde (2.0 mL). After stirring for 3 hr at rt, the reaction was concentrated in vacuo. Prep-HPLC provided 89 mg of compound 706: 1H NMR (500 MHz, CD3OD) 68.34-8.21 (m), 7.80-7.69 (m), 7.51-7.02 (m), 4.99-4.81 (m), 4.73-4.59 (m), 4.57-4.56 (m), 4.35-4.12 (m), 4.07-3.96 (m), 3.93-3.84 (m), 2.64-2.51 (m), 2.49-2.31 (m), 2.29-2.13 (m), 1.02-0.80 (m). ##STR85##

1. concentrationThe reaction was concentrated in vacuo
2. dissolutionThe residue was dissolved in MeOH (10 mL)
3. additiontreated with HOAc (2.0 mL)
4. stirringAfter stirring for 3 hr at rt
5. concentrationthe reaction was concentrated in vacuo