Benzoic Acid → ((2(S)-Benzo(1,3)dioxole-5-carbonylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid

HRID 1456665Notes

Reaction equation

HRID 1456665 reaction equation
C(O)(=O)C1C=CC=CC=1.[C:10]([OH:21])(=O)[C:11]1[CH:19]=[CH:18][C:17]2[O:16][CH2:15][O:14][C:13]=2[CH:12]=1.C([O:26][C:27](=[O:54])[CH2:28][N:29]([C:39](=[O:53])[C@@H:40]([NH:44]C(=O)C1C=CC=CC=1)[CH:41]([CH3:43])[CH3:42])[CH:30]1[CH2:38][C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH2:31]1)(C)(C)C>>[O:16]1[C:17]2[CH:18]=[CH:19][C:11]([C:10]([NH:44][C@@H:40]([CH:41]([CH3:43])[CH3:42])[C:39]([N:29]([CH2:28][C:27]([OH:54])=[O:26])[CH:30]3[CH2:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:31]3)=[O:53])=[O:21])=[CH:12][C:13]=2[O:14][CH2:15]1

Participants

4

Reactant 3

HCID 243Benzoic AcidHCID 71961,3-Benzodioxole-5-carboxylic acidHCID 54431002((2(S)-Benzoylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid t-Butyl Ester

Product 1

HCID 53785635((2(S)-Benzo(1,3)dioxole-5-carbonylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid

Procedure

Compound 728 was prepared by a method similar to the method used to prepare compound 724, except benzoic acid is replaced with piperonylic acid in the preparation of compound 723. ##STR107##

Sources & evidence

ORD record
ord-7d8ee822ef8340d0805860e436084a03
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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