Benzoic Acid → ((2(S)-(3,4,5-Trimethoxybenzoylamino)-3-methylbutyryl)indan-2-ylamino)acetic Acid

HRID 1456667Notes

Reaction equation

HRID 1456667 reaction equation
C(O)(=O)C1C=CC=CC=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:18]=[C:19]([O:23][CH3:24])[C:20]=1[O:21][CH3:22])[C:15]([OH:17])=O.C([O:29][C:30](=[O:57])[CH2:31][N:32]([C:42](=[O:56])[C@@H:43]([NH:47]C(=O)C1C=CC=CC=1)[CH:44]([CH3:46])[CH3:45])[CH:33]1[CH2:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH2:34]1)(C)(C)C>>[CH3:24][O:23][C:19]1[CH:18]=[C:14]([CH:13]=[C:12]([O:11][CH3:10])[C:20]=1[O:21][CH3:22])[C:15]([NH:47][C@@H:43]([CH:44]([CH3:46])[CH3:45])[C:42]([N:32]([CH2:31][C:30]([OH:57])=[O:29])[CH:33]1[CH2:41][C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH2:34]1)=[O:56])=[O:17]

Participants

4

Reactant 3

HCID 243Benzoic AcidHCID 83573,4,5-Trimethoxybenzoic AcidHCID 54431002((2(S)-Benzoylamino-3-methylbutyryl)indan-2-ylamino)acetic Acid t-Butyl Ester

Product 1

HCID 54205516((2(S)-(3,4,5-Trimethoxybenzoylamino)-3-methylbutyryl)indan-2-ylamino)acetic Acid

Procedure

Compound 730 was prepared by a method similar to the method used to prepare compound 724, except benzoic acid is replaced with 3,4,5-trimethoxybenzoic acid in the preparation of 723. ##STR109##

Sources & evidence

ORD record
ord-5a04e788029a40328fa9500db5808028
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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