((2(5)-Benzoylamino-3-methylbutyryl)-(3-methanesulfonylbenzyl)amino)acetic Acid Ethyl Ester → 3(S)-(2-((2(S)-Benzoylamino-methylbutyryl)-(3-methanesulfonylbenzyl)amino)acetylamino)-4-oxo-butyric Acid

HRID 1456674Notes

Reaction equation

HRID 1456674 reaction equation
[C:1]([NH:9][C@@H:10]([CH:32]([CH3:34])C)[C:11]([N:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:14][C:15]([NH:17][C@H:18]([CH:23]=[O:24])[CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:35](OC(=O)CN(C(=O)[C@@H](NC(=O)C1C=CC=CC=1)C(C)C)CC1C=CC=C(NC(OC(C)(C)C)=O)C=1)C.C(OC(=O)CN(C(=O)[C@@H](NC(=O)C1C=CC=CC=1)C(C)C)CC1C=CC=[C:81]([S:85](C)(=[O:87])=[O:86])C=1)C>>[C:1]([NH:9][C@@H:10]([CH2:32][CH2:34][CH3:35])[C:11]([N:13]([CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[C:30]([S:85]([CH3:81])(=[O:87])=[O:86])[CH:31]=1)[CH2:14][C:15]([NH:17][C@H:18]([CH:23]=[O:24])[CH2:19][C:20]([OH:22])=[O:21])=[O:16])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 53767326((2(5)-Benzoylamino-3-methylbutyryl)-(3-methanesulfonylbenzyl)amino)acetic Acid Ethyl EsterHCID 544052433(S)-(2-((2(S)-Benzoylamino-3-methylbutyryl)benzylamino)acetylamino)-4-oxo-butyric AcidHCID 54548631((2(S)-Benzoylamino-3-methylbutyryl)-(3-Bocaminobenzyl)amino)acetic Acid Ethyl Ester

Product 1

HCID 879662003(S)-(2-((2(S)-Benzoylamino-methylbutyryl)-(3-methanesulfonylbenzyl)amino)acetylamino)-4-oxo-butyric Acid

Procedure

Compound 745 was prepared by a method similar to the method used to prepare compound 706, except compound 703 was replaced with compound 744. 1H NMR (CD3OD) δ 8.29 (m), 8.02 (m), 7.82-7.69 (m), 7.51-7.32 (m), 7.29-7.01 (m), 6.98 (d), 4.94-4.38 (m), 4.36 (d), 4.34 (d), 4.30-4.13 (m), 4.04 (d), 3.31-3.19 (m), 2.88-2.77 (m), 2.64-2.48 (m), 2.44-2.32 (m), 2.21 (m), 1.00-0.83 (m). ##STR124##

Sources & evidence

ORD record
ord-72ccb4a805a14ab1833d7eb6cecabe40
Source dataset
uspto-grants-1998_12
Patent number
US05843904

Reaction notes

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