7-chloro-1H-indole → 7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 1456986Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.O.Cl.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:16]1[CH2:17][CH2:18][NH:13][CH2:14][CH:15]=1

Participants

Reactant 2

HCID 1046447-chloro-1H-indole

HCID 2723901Piperonylamine

Product 1

HCID 185458497-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleYield 75%

Procedure

Beginning with 0.70 gm (4.6 mMol) 7-chloro-1H-indole and 1.4 gm (9.2 mMol) 4-piperidone hydrochloride monohydrate, 0.80 gm (75%) of the title compound were recovered as a yellow solid.

Sources & evidence

ORD record: ord-eb5f300aca564dad9e015a880de01ee6
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05846982

Reaction notes

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