1H-Indole, 6-methyl- → 6-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 1456995Notes

Reaction equation

HRID 1456995 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.O.Cl.[NH:13]1[CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]1>>[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:16]3[CH2:17][CH2:18][NH:13][CH2:14][CH:15]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1379281H-Indole, 6-methyl-HCID 2723901Piperonylamine

Product 1

HCID 104207266-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleYield 22%

Procedure

Beginning with 3.0 gm (28.0 mMol) 6-methyl-1H-indole and 7.04 gm (45.7 mMol) 4-piperidone hydrochloride monohydrate, 1.1 gm (22%) of the title compound were recovered as a tan powder.

Sources & evidence

ORD record
ord-7bb73860a30842248a55f3b11d13e2e7
Source dataset
uspto-grants-1998_12
Patent number
US05846982

Reaction notes

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