Methyl 3-(chlorosulfonyl)propanoate → Methyl 3-[2-[2-(4-methylphenyl)ethoxy]ethylaminosulphonyl]propanoate

HRID 1457047Notes

Reaction equation

HRID 1457047 reaction equation
Cl.[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][NH2:14])=[CH:5][CH:4]=1.Cl[S:16]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])(=[O:18])=[O:17]>ClCCl>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][NH:14][S:16]([CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])(=[O:18])=[O:17])=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 4962888Methyl 3-(chlorosulfonyl)propanoateHCID 187790752-[2-(4-Methylphenyl)ethoxy]ethanamine hydrochloride

Product 1

HCID 18779034Methyl 3-[2-[2-(4-methylphenyl)ethoxy]ethylaminosulphonyl]propanoateYield 46.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The subtitle compound (2.49 g) was prepared according to the procedure in example 5 part d using 2-[2-(4-methylphenyl)ethoxy]ethanamine hydrochloride (3.5 g) triethylamine 4.74 ml) methyl 3-(chlorosulphonyl)propanoate (3.08 g), and dichloromethane (80 ml).

Sources & evidence

ORD record
ord-26e8bcc0681a4542908a8ce25098b437
Source dataset
uspto-grants-1998_12
Patent number
US05846989

Reaction notes

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