Cyclopropanecarbonyl chloride → HCID 15428621, compound

HRID 1457059Notes

Reaction equation

O.Cl.Cl.[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=3[C:8]=2[CH2:7]1.CN(C)C1CCC2[O:27][C:28]3[CH:33]=[CH:32][C:31](N)=CC=3C=2C1.Cl.Cl.C1(C(Cl)=O)CC1>>[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:28]([CH:33]4[CH2:31][CH2:32]4)=[O:27])=[CH:13][C:12]=3[C:8]=2[CH2:7]1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 69947452HCID 69947452, compound

Product 1

HCID 15428621HCID 15428621, compound

Procedure

Beginning with 9.0 mg (0.029 mMol) of N,N-dimethyl-8-amino-1,2,3,4-tetrahydro-2-dibenzofuranamine dihydrochloride hemihydrate and 4.3 mg (0.036 mMol) of cyclopropanecarbonyl chloride, the title compound was recovered by the procedure described in Example 2.

Workup

customthe title compound was recovered by the procedure

Sources & evidence

ORD record: ord-a20a83fdc6694128ac99d4ef5956b276
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05846995

Reaction notes

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