Chloride → HCID 21221718, compound

HRID 1457065Notes

Reaction equation

HRID 1457065 reaction equation
[OH2:1].[ClH:2].Cl.[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=3[C:8]=2[CH2:7]1.CN(C)C1CC[C:26]2[O:27][C:28]3C=CC(N)=C[C:29]=3[C:25]=2[CH2:24]1.Cl.Cl.[Cl-]>>[ClH:2].[CH3:4][N:5]([CH3:20])[CH:6]1[CH2:19][CH2:18][C:9]2[O:10][C:11]3[CH:16]=[CH:15][C:14]([NH:17][C:24]([C:25]4[CH:29]=[CH:28][O:27][CH:26]=4)=[O:1])=[CH:13][C:12]=3[C:8]=2[CH2:7]1

Participants

3

Reactant 2

HCID 312ChlorideHCID 69947452HCID 69947452, compound

Product 1

HCID 21221718HCID 21221718, compoundYield 70%

Procedure

Beginning with 0.105 gm (0.35 mMol) of N,N-dimethyl-8-amino-1,2,3,4-tetrahydro-2-dibenzofuranamine dihydrochloride hemihydrate and 0.069 gm (0.53 mMol) furo-3-yl chloride, 0.088 gm (70%) of the title compound were recovered as an off-white solid by the procedure of Example 17.

Sources & evidence

ORD record
ord-0aeffd15e8a4401ab321c69850f815bb
Source dataset
uspto-grants-1998_12
Patent number
US05846995

Reaction notes

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