反应详情

To a mixture of (2S,3R)-3-(4-methylphenyl)-2,3-epoxypropionic acid methyl ester (1.92 g) and methanol (10 ml) is added dropwise a solution of 40% aqueous methylamine solution (2.37 g) in methanol (10 ml) under ice-cooling. The reaction mixture is stirred under ice-cooling for one hour, and concentrated under reduced pressure. To the residue is added ether, and the precipitated crystals are collected by filtration, washed, and dried at 50° C. to give (2S,3R)-3-(4-methylphenyl)-2,3-epoxy-N-methylpropionamide (1.75 g).

1. temperaturecooling
2. temperaturecooling for one hour
3. concentrationconcentrated under reduced pressure
4. additionTo the residue is added ether
5. filtrationthe precipitated crystals are collected by filtration
6. washwashed
7. customdried at 50° C.