反应详情

温度

70 °C

Potassium carbonate is added to dimethyl sulfoxide, and the mixture is stirred at 70° C. The mixture is cooled to room temperature, and thereto is added (2S,3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4-methoxyphenyl)propionamide, and stirred. To the reaction mixture is added dropwise 2-dimethylaminoethyl chloride, and the mixture is stirred at room temperature. The reaction mixture is poured into ice-water, and extracted with ethyl acetate. The extract is dried, and concentrated under reduced pressure to remove the solvent to give (2S,3S)-3-[2-(2-dimethylaminoethylamino)phenylthio]-2-hydroxy-3-(4-methoxyphenyl)-propionamide.

1. temperatureThe mixture is cooled to room temperature
2. stirringstirred
3. stirringthe mixture is stirred at room temperature
4. extractionextracted with ethyl acetate
5. customThe extract is dried
6. concentrationconcentrated under reduced pressure
7. customto remove the solvent