Phenethylamine → HCID 86753414, compound

HRID 1457306Notes

Reaction equation

CO[C:3](=[O:19])[C@H:4]([CH2:15][CH:16]([CH3:18])[CH3:17])[NH:5][C:6]([NH:8][C:9]1[S:10][C:11](=[S:14])[NH:12][N:13]=1)=[O:7].[CH2:20]([NH2:28])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[S:14]=[C:11]1[S:10][C:9]([NH:8][C:6]([NH:5][C@@H:4]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:3]([NH:28][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])=[O:7])=[N:13][NH:12]1

Participants

Reactant 2

HCID 1001Phenethylamine

HCID 10662304HCID 10662304, compound

Product 1

HCID 86753414HCID 86753414, compound

Procedure

Following the general procedure outlined in EXAMPLE 5, and making non-critical variations but starting with N-[[(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-leucine methyl ester (prepared according to the procedure described in EXAMPLE 1) and phenethylamine, the title compound is obtained (mp 215°-217° C., decomposition).

Workup

customprepared

Sources & evidence

ORD record: ord-0b7590a4d94441068949dc4faf4a09a2
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05847148

Reaction notes

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