Phosphoric Acid → HCID 54233355, compound

HRID 1457322Notes

Reaction equation

HRID 1457322 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:13].O.[C:15]([OH:19])(=[O:18])[CH:16]=O.P(=O)(O)(O)O>O>[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[CH:16][C:15]([OH:19])=[O:18])[C:7]2=[O:13]

Participants

5

Reactant 3

HCID 1004Phosphoric AcidHCID 143687015,7-Difluoro-3,4-dihydronaphthalen-1(2H)-oneHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 54233355HCID 54233355, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 5,7-difluoro-3,4-dihydro-1(2H)-naphthalenone (3.2 g), glyoxylic acid monohydrate (1.6 g) and 85% phosphoric acid (3 ml) was heated with stirring at 90° C. for four hours. After cooling, water was added to the reaction solution, and the precipitated crystals were collected by filtration, washed with water, and dried to give (5,7-difluoro-3,4-dihydro-1-oxo-2(1H)-naphthalenylidene)acetic acid (4.2).

Workup

  1. temperaturewas heated
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-4da6063f6f8c4be093017d0d15b90d54
Source dataset
uspto-grants-1998_12
Patent number
US05847159

Reaction notes

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