Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | 5,7-Difluoro-3,4-dihydronaphthalen-1(2H)-one | HCID 14368701 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 54233355 | HCID 54233355 | — |
Reaction Steps
A mixture of 5,7-difluoro-3,4-dihydro-1(2H)-naphthalenone (3.2 g), glyoxylic acid monohydrate (1.6 g) and 85% phosphoric acid (3 ml) was heated with stirring at 90° C. for four hours. After cooling, water was added to the reaction solution, and the precipitated crystals were collected by filtration, washed with water, and dried to give (5,7-difluoro-3,4-dihydro-1-oxo-2(1H)-naphthalenylidene)acetic acid (4.2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05847159 |
|---|
| Source dataset | uspto-grants-1998_12 |
|---|
| ORD ID | ord-4da6063f6f8c4be093017d0d15b90d54 |
|---|
| Source note | uspto-grants-1998_12 |
|---|
