Potassium Bromide → HCID 86585538, compound

HRID 1457451Notes

Reaction equation

HRID 1457451 reaction equation
C(C1NC(C(N[C@H](C(NC(C=O)CC(O)=O)=O)C)=O)=CC=1)C1C=CC=CC=1.C([C:35]1[NH:39][C:38]([C:40]([NH:42][C@@H:43]([C:45]([NH:47][C@H:48]2[CH2:52][C:51](=[O:53])[O:50][C@@H:49]2[O:54][CH2:55][C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)=[O:46])[CH3:44])=[O:41])=[CH:37][CH:36]=1)C1C=CC=CC=1.N1C=CC=C1C(N[C@H](C(NC(C=O)CC(O)=O)=O)C)=O.[K+].[Br-]>O.CO>[NH:39]1[CH:35]=[CH:36][CH:37]=[C:38]1[C:40]([NH:42][C@@H:43]([C:45]([NH:47][C@H:48]1[CH2:52][C:51](=[O:53])[O:50][C@@H:49]1[O:54][CH2:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1)=[O:46])[CH3:44])=[O:41]

Participants

7

Reactant 4

HCID 253877Potassium BromideHCID 22875484HCID 22875484, compoundHCID 22875487HCID 22875487, compoundHCID 86619228HCID 86619228, compound

Product 1

HCID 86585538HCID 86585538, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-[N-(5-Benzylpyrrole-2-carbonyl)-L-alaninyl]amino-4-oxobutanoic acid (36b), was prepared (41%) from 35b by the method described for compound 36a, to afford an off white solid: mp. 109°-112° C.; [α]D25 +6.3° (c 0.3, methanol); IR (KBr) 3368, 1724, 1630, 1530, 1453, 1414, 1233, 1049; 1H NMR(d4 methanol) δ 7.25-7.11 (5H, m), 6.76 (1H, d, J=3.5), 5.84 (1H, d, J=3.5), 4.51 (1H, m), 4.43 (1H, q, J=7.1), 4.23 (1H, m), 2.5 (2H, m),1.35 (3H, d, J=7.0). Anal. Calcd for C19H21N3O5.1.75 H2O: C, 56.64; H, 6.13; N, 10.43. Found: C, 56.34; H, 5.72; N, 10.00. ##STR128##

Workup

  1. customto afford an off white solid

Sources & evidence

ORD record
ord-96e314cb5ec742f9b8b1f81c7ad9e7b9
Source dataset
uspto-grants-1998_12
Patent number
US05847135

Reaction notes

Loading…