Tobramycin → HCID 86753426, compound

HRID 1457519Notes

Reaction equation

[CH2:1]1[C@@H:6]([NH2:7])[C@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@H:11]([NH2:18])[C@H:10]2[OH:19])[C@@H:4]([OH:20])[C@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][NH2:29])[C@@H:25]([OH:30])[CH2:24][C@H:23]2[NH2:31])[C@H:2]1[NH2:32].[OH:33][C:34]([CH2:36][CH2:37][CH2:38][CH2:39][C@H:40]1[C@@H:48]2[C@@H:43]([NH:44][C:45]([NH:47]2)=[O:46])[CH2:42][S:41]1)=[O:35].C1N=CN(C(N2C=NC=C2)=O)C=1>>[CH2:1]1[C@@H:6]([NH2:7])[C@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@H:11]([NH2:18])[C@H:10]2[OH:19])[C@@H:4]([OH:20])[C@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][NH2:29])[C@@H:25]([OH:30])[CH2:24][C@H:23]2[NH2:31])[C@H:2]1[NH2:32].[OH:35][C:34]([CH2:36][CH2:37][CH2:38][CH2:39][C@H:40]1[C@@H:48]2[C@@H:43]([NH:44][C:45]([NH:47]2)=[O:46])[CH2:42][S:41]1)=[O:33]

Participants

Reactant 3

HCID 36294Tobramycin

HCID 682631,1'-Carbonyldiimidazole

HCID 171548Biotin

Product 1

HCID 86753426HCID 86753426, compound

Procedure

A second tobramycin-biotin-avidin conjugate was prepared as set forth above in this Example, but using molar ratios of tobramicin to biotin to CDI/NHS of 30:1:1.3.

Sources & evidence

ORD record: ord-833e1e0f5ffc4ef59564d6e4a7b89240
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05849599

Reaction notes

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