HCID 22099221, compound → HCID 15300822, compound

HRID 1457522Notes

Reaction equation

HRID 1457522 reaction equation
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]([NH:19][NH:20][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[CH:16]=[CH:15][C:10]=1[C:11]([O:13][CH3:14])=[O:12])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:21]([NH:20][NH:19][C:17]1[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([S:6](=[O:7])(=[O:8])[NH2:5])[CH:18]=1)(=[O:25])[CH:22]([CH3:24])[CH3:23]

Participants

3

Reactant 1

HCID 22099221HCID 22099221, compound

Product 1

HCID 15300822HCID 15300822, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1.0 g (2.7 mmol) of methyl 2-(N-tert-butylsulfamoyl)-4-(2-isobutyrylhydrazino)benzoate is stirred in 10 ml of trifluoroacetic acid at 25° C. for 2 hours. The mixture is evaporated and the residue is triturated with diethyl ether. Filtration with suction and drying gives 0.8 g (94% of theory) of methyl 4-(2-isobutyrylhydrazino)-2-sulfamoylbenzoate of melting point 198°-200° C.

Workup

  1. customThe mixture is evaporated
  2. customthe residue is triturated with diethyl ether
  3. filtrationFiltration with suction
  4. customdrying

Sources & evidence

ORD record
ord-b4c9938241b24066838fbafcb88b0495
Source dataset
uspto-grants-1998_12
Patent number
US05849666

Reaction notes

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