Hydrochloric Acid → HCID 70128325, compound

HRID 1457527Notes

Reaction equation

HRID 1457527 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20](=[O:28])[CH2:21][N:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)[CH:18]=3)[NH:13][C:12]2=[O:29])=[CH:2]1.[ClH:30]>O>[ClH:30].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=[C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:20](=[O:28])[CH2:21][N:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)[CH:18]=3)[NH:13][C:12]2=[O:29])=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54364444HCID 54364444, compound

Product 1

HCID 70128325HCID 70128325, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 3-(indol-3-ylmethylene)-5-(2-piperidin-1-yl-acetyl)-2-indolinone (25 mg) in water (10 ml) Amberlite Ira 900® (HCl form) was added until the solution turned clear. The resin was filtered and washed with water and the solution freeze-dried to give 3-(indol-3-ylmethylene)-5-(2-piperidin-1-yl-acetyl)-2-indolinone hydrochloride (20 mg).

Workup

  1. additionwas added until the solution
  2. filtrationThe resin was filtered
  3. washwashed with water
  4. customthe solution freeze-dried

Sources & evidence

ORD record
ord-ffdf3c5a136d4bb28bf65707f369c0b2
Source dataset
uspto-grants-1998_12
Patent number
US05849710

Reaction notes

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