反应详情

温度

70 °C

Composition 4 (3.05 g) was dissolved in dry pyridine (50 ml), chlorotriphenyl-methane (5.01 g) was added and the reaction mixture was stirred at 70° C. for three hours. It was cooled to 0° C., acetic anhydride (6.36 ml) was added dropwise and the mixture was stirred overnight at room temperature. It was poured into ice-water and was diluted with chloroform (300 ml). The organic layer was washed subsequently with water, 2M hydrochloric acid, water, was dried and evaporated to leave 2,3,4-tri-O-acetyl-6-O-trityl-β-D-glucopyranosyl azide (5, 7.67 g, 90%).

1. temperatureIt was cooled to 0° C.
2. stirringthe mixture was stirred overnight at room temperature
3. washThe organic layer was washed subsequently with water, 2M hydrochloric acid, water
4. customwas dried
5. customevaporated