6-trifluoroacetamido-7-nitro-2,3(1H,4H)-quinoxalinedione → 6-Amino-7-nitroquinoxaline-2,3-diol

HRID 1457561Notes

Reaction equation

HRID 1457561 reaction equation
FC(F)(F)C([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17])[NH:12][C:11](=[O:19])[C:10](=[O:20])[NH:9]2)=O>C(O)C.Cl>[NH2:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17])[NH:12][C:11](=[O:19])[C:10](=[O:20])[NH:9]2

Participants

4

Reactant 1

HCID 220971576-trifluoroacetamido-7-nitro-2,3(1H,4H)-quinoxalinedione

Product 1

HCID 39809926-Amino-7-nitroquinoxaline-2,3-diolYield 84%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

A solution of 41 g (0.13 mol) of 6-trifluoroacetamido-7-nitroquinoxaline -2,3(1H,4H)-dione in 300 ml of ethanol and 700 ml of 3 molar hydrochloric acid was refluxed for 3 hours. After the mixture had cooled, the precipitated crude product was filtered off with suction and washed with acetone. Yield: 84%. Melting point >330° C.

Workup

  1. temperatureAfter the mixture had cooled
  2. customthe precipitated crude product
  3. filtrationwas filtered off with suction
  4. washwashed with acetone

Sources & evidence

ORD record
ord-3a051c9538734ff88e07e49e762d2de2
Source dataset
uspto-grants-1998_12
Patent number
US05849743

Reaction notes

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