Phosgene → {2-[3-((1S)-1-methoxycarbonyl-2-phenylethyl)ureido]-4-methoxy-6-tert-butylphenoxy}methoxymethane
Reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:3]=1[O:4][CH2:5][O:6][CH3:7].[C:18](Cl)(Cl)=[O:19].[CH3:22][O:23][C:24](=[O:34])[C@H:25]([CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[NH2:26]>>[CH3:22][O:23][C:24]([C@@H:25]([NH:26][C:18](=[O:19])[NH:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:3]=1[O:4][CH2:5][O:6][CH3:7])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:34]Participants
4
Procedure
(2-Amino-4-methoxy-6-tert-butylphenoxy)methoxymethane, phosgene and L-phenylalanine methyl ester were treated in the same manner as described in Example 16 (1) to give {2-[3-((1S)-1-methoxycarbonyl-2-phenylethyl)ureido]-4-methoxy-6-tert-butylphenoxy}methoxymethane.
Sources & evidence
- ORD record
- ord-e4572efd9c7141f39f4453fc3477b317
- Source dataset
- uspto-grants-1998_12
- Patent number
- US05849732
Reaction notes
Loading…