1,4-Dioxane hydrochloride → HCID 22099425, compound

HRID 1457590Notes

Reaction equation

HRID 1457590 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][N:22]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:23](=[O:38])[NH:24][C:25]2[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[C:27]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:26]=2[OH:37])[CH2:17][CH2:16]1)=O)(C)(C)C>>[ClH:1].[NH:15]1[CH2:20][CH2:19][CH:18]([CH2:21][N:22]([CH2:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:23](=[O:38])[NH:24][C:25]2[CH:30]=[C:29]([O:31][CH3:32])[CH:28]=[C:27]([C:33]([CH3:36])([CH3:35])[CH3:34])[C:26]=2[OH:37])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22099480HCID 22099480, compound

Product 1

HCID 22099425HCID 22099425, compoundYield 69%

Procedure

4N hydrogen chloride-dioxane solution (15 ml) was added to 1.50 g of 2-[3-(1-tert-butoxycarbonylpiperidin-4-yl)methyl-3-phenylmethylureido]-4-methoxy-6-tert-butylphenol, and the mixture was stirred at room temperature for 2 hours. Then, the mixture was evaporated to dryness under reduced pressure and the residue was recrystallized from an ethanol solution to give 0.912 g of 2-[3-(4-piperidylmethyl)-3-phenylmethylureido]-4-methoxy-6-tert-butylphenol hydrochloride (yield: 69%, melting point: 195°-196° C.).

Workup

  1. customThen, the mixture was evaporated to dryness under reduced pressure
  2. customthe residue was recrystallized from an ethanol solution

Sources & evidence

ORD record
ord-194fe921009243bf8f515d9837d530ce
Source dataset
uspto-grants-1998_12
Patent number
US05849732

Reaction notes

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