1,4-Dioxane hydrochloride → HCID 22099425, compound

Participants

Reaction Steps

4N hydrogen chloride-dioxane solution (15 ml) was added to 1.50 g of 2-[3-(1-tert-butoxycarbonylpiperidin-4-yl)methyl-3-phenylmethylureido]-4-methoxy-6-tert-butylphenol, and the mixture was stirred at room temperature for 2 hours. Then, the mixture was evaporated to dryness under reduced pressure and the residue was recrystallized from an ethanol solution to give 0.912 g of 2-[3-(4-piperidylmethyl)-3-phenylmethylureido]-4-methoxy-6-tert-butylphenol hydrochloride (yield: 69%, melting point: 195°-196° C.).

Provenance & Evidence