反应详情

Conc. sulfuric acid (0.4 ml) was added to a mixed solution comprising 3.3 g of 2,4-dimethoxybenzaldehyde and 30 ml of methanol, and under ice-cooling, 2.93 ml of 30% hydrogen peroxide aqueous solution was added to the mixture. After stirring at room temperature for 4 hours, a 5% aqueous potassium hydrogen sulfite solution was added to the mixture and the solvent was removed under reduced pressure. The residue was extracted with diethyl ether, the extract was washed and dried and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (solvent; hexane:ethyl acetate=4:1) to give 2.1 g of 2,4-dimethoxyphenol (yield: 69%, state: colorless oily product).

1. temperatureunder ice-cooling
2. customthe solvent was removed under reduced pressure
3. extractionThe residue was extracted with diethyl ether
4. washthe extract was washed
5. customdried
6. customthe solvent was removed under reduced pressure
7. customThe residue was purified by silica gel column chromatography (solvent; hexane:ethyl acetate=4:1)