反应详情

A mixture of 3.7 g of N-(tert-butoxycarbonyl)piperazine, 2.5 g of bromodiphenylmethane, 6.9 g of potassium carbonate and 20 ml of hexamethylphosphoramide was stirred at 40° to 50° C. for 4 hours. After cooling, water was added and the reaction mixture was extracted with diethyl ether. The exact was washed and dried, and the solvent was removed under reduced pressure. Hexane was added to the precipitated crystals and the crystals were collected by filtration to give 2.5 g of 4-(tert-butoxycarbonyl)-1-diphenylmethylpiperazine (melting point: 129°-131° C.).

1. temperatureAfter cooling
2. extractionthe reaction mixture was extracted with diethyl ether
3. washThe exact was washed
4. customdried
5. customthe solvent was removed under reduced pressure
6. additionHexane was added to the precipitated crystals
7. filtrationthe crystals were collected by filtration