反应详情

A mixture of 3.0 g of methyl 2-(2-pyridinyl)benzoate and 600 mg of sodium hydroxide in 50 ml of 9:1 methanol:water is refluxed for 4 hours. The reaction mixture is concentrated in vacuo and the residue dissolved in 50 ml of cold water. The solution is neutralized with glacial acetic acid and the resulting product filtered, washed with water, and dried to give 2.5 g of the desired product:M+1=200.

1. concentrationThe reaction mixture is concentrated in vacuo
2. dissolutionthe residue dissolved in 50 ml of cold water
3. filtrationthe resulting product filtered
4. washwashed with water
5. customdried