反应详情

A mixture of 0.198 g of 5,6-dihydropyrido[2,3-b][1,5]benzoxazepine, 0.155 g of N,N-diisopropylethylamine and 0.444 g of 4-[([1,1-biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chloride in 12 ml of dichloromethane is stirred at room temperature for 2.5 hours. The mixture is poured into water and extracted with dichloromethane. The extract is washed with 2N Na2CO3, H2O, brine and dried (Na2 SO4). The solution is passed through a thin pad of hydrous magnesium silicate. The filter pad is washed with 50 ml of hexane-ethyl acetate (1:2) and the filtrate concentrated to dryness.

1. extractionextracted with dichloromethane
2. washThe extract is washed with 2N Na2CO3, H2O, brine
3. customdried (Na2 SO4)
4. washThe filter pad is washed with 50 ml of hexane-ethyl acetate (1:2)
5. concentrationthe filtrate concentrated to dryness