HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl][1,1'-biphenyl]-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]-3-pyridinecarbonyl chloride | HCID 22099792 | — |
| Reactant | 5,6-Dihydropyrido[2,3-b][1,4]benzoxazepine | HCID 22099816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl][1,1'-biphenyl]-2-carboxamide | HCID 22099774 | — |
Reaction Steps
As described for Example 66, the reaction of 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine (0.198 g) with 6-[([1,1'-biphenyl]-2-carbonyl)amino]pyridine-3-carbonyl chloride (0.404 g) in dichloromethane in the presence of N,N-diisopropylethylamine (0.155 g) gives the product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849735 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-e1f8a9dbb3834d03a2a7271cd74dcfc2 |
| Source note | uspto-grants-1998_12 |