Diisopropylethylamine → N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl][1,1'-biphenyl]-2-carboxamide

HRID 1457696Notes

Reaction equation

HRID 1457696 reaction equation
[N:1]1[C:6]2[O:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:16]1([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:17]([C:22]([NH:24][C:25]2[N:30]=[CH:29][C:28]([C:31](Cl)=[O:32])=[CH:27][CH:26]=2)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=1.C(N(CC)C(C)C)(C)C>ClCCl>[N:1]1[C:6]2[O:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][N:11]([C:31]([C:28]3[CH:27]=[CH:26][C:25]([NH:24][C:22]([C:17]4[C:16]([C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[O:23])=[N:30][CH:29]=3)=[O:32])[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 22099792HCID 22099792, compoundHCID 220998165,6-Dihydropyrido[2,3-b][1,4]benzoxazepine

Product 1

HCID 22099774N-[5-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-2-pyridinyl][1,1'-biphenyl]-2-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As described for Example 66, the reaction of 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine (0.198 g) with 6-[([1,1'-biphenyl]-2-carbonyl)amino]pyridine-3-carbonyl chloride (0.404 g) in dichloromethane in the presence of N,N-diisopropylethylamine (0.155 g) gives the product as a solid.

Sources & evidence

ORD record
ord-e1f8a9dbb3834d03a2a7271cd74dcfc2
Source dataset
uspto-grants-1998_12
Patent number
US05849735

Reaction notes

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