HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[4-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-3-chlorophenyl][1,1'biphenyl]-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[([1,1'-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chloride | HCID 22099600 | — |
| Reactant | 5,6-Dihydropyrido[2,3-b][1,4]benzoxazepine | HCID 22099816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-3-chlorophenyl][1,1'biphenyl]-2-carboxamide | HCID 22099899 | — |
Reaction Steps
As described for Example 66, reaction of 0.198 g of 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine with 0.444 g of 4-[([1,1'-biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chloride in dichloromethane in the presence of N,N-diisopropylethylamine gives the product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05849735 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-2c0376116db74c17853c35323b9d9315 |
| Source note | uspto-grants-1998_12 |