Diisopropylethylamine → N-[4-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-3-chlorophenyl][1,1'biphenyl]-2-carboxamide

HRID 1457697노트

반응식

HRID 1457697 반응식
[N:1]1[C:6]2[O:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][NH:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:16]1([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:17]([C:22]([NH:24][C:25]2[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[C:27]([Cl:34])[CH:26]=2)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=1.C(N(CC)C(C)C)(C)C>ClCCl>[N:1]1[C:6]2[O:7][C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=3[CH2:10][N:11]([C:29]([C:28]3[CH:32]=[CH:33][C:25]([NH:24][C:22]([C:17]4[C:16]([C:35]5[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=5)=[CH:21][CH:20]=[CH:19][CH:18]=4)=[O:23])=[CH:26][C:27]=3[Cl:34])=[O:30])[C:5]=2[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 220996004-[([1,1'-Biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chlorideHCID 220998165,6-Dihydropyrido[2,3-b][1,4]benzoxazepine

생성물 1

HCID 22099899N-[4-(Pyrido[2,3-b][1,4]benzoxazepin-5(6H)-ylcarbonyl)-3-chlorophenyl][1,1'biphenyl]-2-carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

As described for Example 66, reaction of 0.198 g of 5,6-dihydropyrido[2,3-b][1,4]benzoxazepine with 0.444 g of 4-[([1,1'-biphenyl]-2-carbonyl)amino]-2-chlorobenzoyl chloride in dichloromethane in the presence of N,N-diisopropylethylamine gives the product as a solid.

출처 및 근거

ORD 기록
ord-2c0376116db74c17853c35323b9d9315
출처 데이터셋
uspto-grants-1998_12
특허 번호
US05849735

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