Sodium hydride → HCID 18784500, Verbindung

HRID 1457743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1457743
[H-].[Na+].Cl.[F:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[NH:10])=[CH:7][CH:6]=1.[CH:14]([CH:16]([CH3:21])[C:17](OC)=O)=[O:15]>C(O)C>[F:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]2[NH:11][C:14](=[O:15])[C:16]([CH3:21])=[CH:17][N:10]=2)=[CH:7][CH:6]=1

Komponenten

5

Edukt 3

HCID 24758Sodium hydrideHCID 103507Propanoic acid, 2-methyl-3-oxo-, methyl esterHCID 124561604-Fluorobenzamidine Hydrochloride

Produkt 1

HCID 18784500HCID 18784500, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Sodium hydride (0.52 g, 13 mmol) is added to 20 mL of anhydrous ethanol and stirred for 30 minutes at ambient temperature. To this, 4-fluorobenzamidine hydrochloride (1.47 g, 8.5 mmol) (from example 40) is added and the mixture is stirred for further 30 minutes. Methyl 2-formylpropionate (1 g, 10.6 mmol) is added dropwise and the reaction mixture is left for 4 days under stirring at ambient temperature.

Aufarbeitung

  1. stirringthe mixture is stirred for further 30 minutes
  2. waitthe reaction mixture is left for 4 days
  3. stirringunder stirring at ambient temperature

Quellen und Nachweise

ORD-Eintrag
ord-360a814081644a2ebcf5256a04442bb4
Quelldatensatz
uspto-grants-1998_12
Patentnummer
US05849758

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