4-Pyridinecarboxaldehyde → HCID 12855467, compound

HRID 1457821Notes

Reaction equation

HRID 1457821 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1[SH:8].[N:13]1[CH:18]=[CH:17][C:16]([CH:19]=O)=[CH:15][CH:14]=1>>[F:11][C:9]([F:12])([F:10])[C:4]1[CH:5]=[CH:6][C:7]2[S:8][C:19]([C:16]3[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=3)=[N:1][C:2]=2[CH:3]=1

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 880422-Amino-4-(trifluoromethyl)benzenethiol

Product 1

HCID 12855467HCID 12855467, compoundYield 89.2%

Procedure

3-Amino-4-mercaptobenzotrifluoride (8.5 g, 0.04 mol) and 4-pyridine carboxaldehyde (4.2 ml, 0.04 mol) were reacted as exemplified in Example 7 step 1, to afford the title compound as a brown solid (10 g, 89%). δH (CDCl3), 7.69 (1H, d of d, J 8.4Hz, J 1.7Hz, ArH), 7.93 (2H, m, ArH), 8.06 (1H, d, J 8.4Hz, ArH), 8.40 (1H, d, J 0.7Hz, ArH), 8.81 (2H, m, ArH). m/z (ES+) 281 (M+1)+.

Sources & evidence

ORD record
ord-0d25615a38b94269ba8b89626af9e9a2
Source dataset
uspto-grants-1998_12
Patent number
US05849765

Reaction notes

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