Hydrazine hydrate (1:1) → HCID 178469928, compound

HRID 1457920Notes

Reaction equation

HRID 1457920 reaction equation
[CH2:1]([O:3][CH:4]=[C:5]([C:11]#[N:12])[C:6](OCC)=O)[CH3:2].[OH2:13].[NH2:14][NH2:15]>C(O)C>[NH2:12][C:11]1[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:13])=[CH:6][NH:15][N:14]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester

Product 1

HCID 178469928HCID 178469928, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl (ethoxymethylene)cyanoacetate (10 g) in ethanol (100 ml), was added hydrazine monohydrate (2.87 ml), and the resulted mixture was refluxed for 12 h. The reaction mixture was evaporated under reduced pressure followed by addition of ether (50 ml), and 3-amino-4-ethoxycarbonylpyrazole was obtained as pale yellow crystals (7.68 g, yield 84%).

Workup

  1. temperaturethe resulted mixture was refluxed for 12 h
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionfollowed by addition of ether (50 ml)

Sources & evidence

ORD record
ord-8f5102df150f42d282019d6ff336edbf
Source dataset
uspto-grants-1998_12
Patent number
US05849779

Reaction notes

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