Phenyl isocyanate → HCID 22101199, compound

HRID 1457926Notes

Reaction equation

HRID 1457926 reaction equation
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].[C:13]1([N:19]=[C:20]=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C>C1C=CC=CC=1>[C:13]1([NH:19][C:20]([NH:1][C:2]2[N:6]([CH3:7])[N:5]=[CH:4][C:3]=2[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 7672Phenyl isocyanateHCID 8471TriethylamineHCID 271299Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate

Product 1

HCID 22101199HCID 22101199, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 5-amino-4-ethoxycarbonyl-1-methylpyrazole (0.845 g) in benzene (50 ml), were added phenyl isocyanate (0.543 ml) and triethylamine (0.70 ml), and the mixture was refluxed in a sealed tube for 3 h. The reaction mixture was evaporated under reduced pressure followed by repeated addition of ether, and the title compound was obtained as crystals (0.36 g, yield 25%).

Workup

  1. temperaturethe mixture was refluxed in a sealed tube for 3 h
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionaddition of ether

Sources & evidence

ORD record
ord-54397bc091ef4e908b738cc5707139c8
Source dataset
uspto-grants-1998_12
Patent number
US05849779

Reaction notes

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