反应详情

A solution of 1.8 g of methyl 2-methyl-4-bromo-5-methylsulphonylbenzoate [obtainable in accordance with Ex. 1] and 1.5 g of guanidine in 50 ml of methanol is boiled for five hours, and the solvent is subsequently removed. The residue is treated with water and the remaining crystalline crop is filtered off with suction and treated with dil. sodium hydroxide solution. The solid residue is filtered off and recrystallized from ethanol, and N-diaminomethylene-2-methyl-4-bromo-5-methylsulphonylbenzamide is obtained, m.p. 207°-208°.

1. customthe solvent is subsequently removed
2. additionThe residue is treated with water
3. filtrationthe remaining crystalline crop is filtered off with suction
4. additiontreated with dil. sodium hydroxide solution
5. filtrationThe solid residue is filtered off
6. customrecrystallized from ethanol