Hydrochloric Acid → HCID 17760595, compound

Participants

Reaction Conditions

Reaction Steps

The 4-(4 -ethoxycarbonylpiperidino)-5-hydroxy-2,6,6-trimethyl-2-cyclohepten-1-one obtained in Example 24 (0.68 g, 2.1 millimoles) was dissolved in acetic acid (5 ml), 6N hydrochloric acid (2 ml) was added and the mixture was heated at 80° C. for 90 minutes. Concentration to dryness followed by washing with ethyl acetate gave 0.56 g (80.2%) of 4-(4 -carboxypiperidino)-5-hydroxy-2,6,6-trimethyl-2-cyclohepten-1-one hydrochloride.

Provenance & Evidence