Hydrochloric Acid → HCID 17760595, compound

HRID 1457953Notes

Reaction equation

HRID 1457953 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH:18]([OH:19])[C:17]([CH3:21])([CH3:20])[CH2:16][C:15](=[O:22])[C:14]([CH3:23])=[CH:13]2)[CH2:8][CH2:7]1)=[O:5])C.[ClH:24]>C(O)(=O)C>[ClH:24].[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH:12]2[CH:18]([OH:19])[C:17]([CH3:20])([CH3:21])[CH2:16][C:15](=[O:22])[C:14]([CH3:23])=[CH:13]2)[CH2:8][CH2:7]1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22101526HCID 22101526, compound

Product 1

HCID 17760595HCID 17760595, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

The 4-(4 -ethoxycarbonylpiperidino)-5-hydroxy-2,6,6-trimethyl-2-cyclohepten-1-one obtained in Example 24 (0.68 g, 2.1 millimoles) was dissolved in acetic acid (5 ml), 6N hydrochloric acid (2 ml) was added and the mixture was heated at 80° C. for 90 minutes. Concentration to dryness followed by washing with ethyl acetate gave 0.56 g (80.2%) of 4-(4 -carboxypiperidino)-5-hydroxy-2,6,6-trimethyl-2-cyclohepten-1-one hydrochloride.

Workup

  1. concentrationConcentration to dryness
  2. washby washing with ethyl acetate

Sources & evidence

ORD record
ord-6c3caf1a701e4f77af0b57587be12f13
Source dataset
uspto-grants-1998_12
Patent number
US05849801

Reaction notes

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